2. Signaling Pathways
  3. GPCR/G Protein
    Neuronal Signaling
  4. Somatostatin Receptor

Somatostatin Receptor

SSTRs; SSTR

Somatostatin Receptor

Related Products

PDF 0.61 MB

Somatostatin receptors (SSTR1, 2A and B, 3, 4 and 5) belong to the G protein coupled receptor family. Somatostatin receptors are expressed in a variety of human tumors, including most tumors of neuroendocrine origin, breast tumors, certain brain tumors, renal cell tumors, lymphomas, and prostate cancer. Somatostatin triggers cytostatic and cytotoxic effects and has a general inhibitory effect on secretion mediated through its interaction with somatostatin receptors.

The SSTRs 1-4 display weak selectivity for somatostatin-14 binding, whereas SSTR5 is somatostatin-28-selective. Based on structural similarity and reactivity for octapeptide and hexapeptide somatostatin receptor analogs, SSTRs 2, 3 and SSTR5 belong to a similar somatostatin receptor subclass; SSTRs 1-4 react poorly with these analogs and belong to a separate subclass. All five somatostatin receptors are functionally coupled to inhibition of adenylyl cyclase via pertussis toxin-sensitive guanosine triphosphate (GTP)-binding proteins. mRNA for SSTRs 1-5 is widely expressed in brain and peripheral organs and displays an overlapping but characteristic pattern that is subtype-selective and tissue- and species-specific. All pituitary cell subsets express SSTR2 and SSTR5, with SSTR5 being more abundant. Individual pituitary cells coexpress multiple somatostatin receptor subtypes.

Somatostatin Receptor Isoform Specific Products:

Somatostatin Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-RS13822
    Sstr1 Rat Pre-designed siRNA Set A
    		Inhibitor

    Sstr1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Sstr1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Sstr1 Rat Pre-designed siRNA Set A
  • HY-RS13830
    Sstr4 Mouse Pre-designed siRNA Set A
    		Inhibitor

    Sstr4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sstr4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Sstr4 Mouse Pre-designed siRNA Set A
  • HY-RS13820
    SSTR1 Human Pre-designed siRNA Set A
    		Inhibitor

    SSTR1 Human Pre-designed siRNA Set A contains three designed siRNAs for SSTR1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    SSTR1 Human Pre-designed siRNA Set A
  • HY-RS13821
    Sstr1 Mouse Pre-designed siRNA Set A
    		Inhibitor

    Sstr1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sstr1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Sstr1 Mouse Pre-designed siRNA Set A
  • HY-RS13824
    Sstr2 Mouse Pre-designed siRNA Set A
    		Inhibitor

    Sstr2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sstr2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Sstr2 Mouse Pre-designed siRNA Set A
  • HY-125673
    AC-178335
    AC-178335 is a SRIF antagonist, with a Ki of 172 nM. AC-178335 blocks SRIF inhibition of adenylate cyclase in vitro (IC50=5.1 μM). AC-178335 induces GH release in anesthetized rats.
    AC-178335
  • HY-P3955
    RC-160 [Lys(Boc)]
    RC-160 [Lys(Boc)], a 8-aa peptide, is a Somatostatin analog.
    RC-160 [Lys(Boc)]
  • HY-P1203A
    BIM-23056 TFA
    		Antagonist
    BIM 23056 TFA, a linear octapeptide, is a potent sst3 and sst5 somatostatin receptor antagonist with Ki values of 10.8, 5.7, respectively.
    BIM-23056 TFA
  • HY-P4992
    Tyr-(D-Dab4,Arg5,D-Trp8)-cyclo-Somatostatin-14 (4-11)
    		Agonist
    Tyr-(D-Dab4,Arg5,D-Trp8)-cyclo-Somatostatin-14 (4-11) is a somatostatin agonist that can be used in cancer research.
    Tyr-(D-Dab4,Arg5,D-Trp8)-cyclo-Somatostatin-14 (4-11)
  • HY-182905
    SSTR5/TGR5-modulator-1
    		Modulator
    SSTR5/TGR5-modulator-1 is an orally active and dual-target small molecule, balanced in vitro activity at human TGR5 and human SSTR5. SSTR5/TGR5-modulator-1 activates human TGR5 to promote cAMP accumulation. SSTR5/TGR5-modulator-1 blocks human SSTR5 to inhibit agonist-induced calcium mobilization. SSTR5/TGR5-modulator-1 improves glucose tolerance in mice. SSTR5/TGR5-modulator-1 alleviates gallbladder filling in mice at pharmacologically relevant doses. SSTR5/TGR5-modulator-1 has suboptimal physicochemical and metabolic properties.SSTR5/TGR5-modulator-1 can be used for the research of type 2 diabetes mellitus.
    SSTR5/TGR5-modulator-1
  • HY-P3124
    BIM-23190
    		Agonist
    BIM-23190, a somatostatin analog, a selective SSTR2 and SSTR5 agonist, exhibits Ki values of 0.34 nM and 11.1 nM for SSTR2 and SSTR5, respectively. BIM-23190 can be used in the study for cancer and acromegaly.
    BIM-23190
  • HY-P0036B
    Octreotide pamoate
    		Agonist
    Octreotide (SMS 201-995) pamoate is a somatostatin receptor agonist and synthetic octapeptide endogenous somatostatin analogue. Octreotide pamoate can bind to the somatostatin receptors which are mainly subtypes 2, 3 and 5. Octreotide pamoate increases Gi activity and reduces intracellular cAMP production. Octreotide pamoate has antitumor activity, mediates apoptosis and may also be used in disease studies in acromegaly.
    Octreotide pamoate
  • HY-110161
    sst2 Receptor agonist-1
    		Agonist
    sst2 Receptor agonist-1 is a potent somatostatin receptor subtype 2 (sst2) agonist with a Ki value of 0.025 nM and a cAMP IC50 value of 4.8 nM. sst2 Receptor agonist-1 can inhibit rat growth hormone (GH) secretion and ocular neovascular lesion formation. Antiangiogenic effect.
    sst2 Receptor agonist-1
  • HY-P11234
    Axareotide
    Axareotide is a somatostatin analogue.
    Axareotide
  • HY-P1201A
    Cyclosomatostatin TFA
    		Antagonist
    Cyclosomatostatin TFA is a potent somatostatin (SST) receptor antagonist. Cyclosomatostatin TFA can inhibit somatostatin receptor type 1 (SSTR1) signaling and decreases cell proliferation, ALDH+ cell population size and sphere-formation in colorectal cancer (CRC) cells.
    Cyclosomatostatin TFA
  • HY-105172A
    TT-232 TFA
    		Agonist
    TT-232 TFA (CAP-232 TFA) is an analogue of somatostatin. TT-232 TFA can induce apoptosis of pancreatic tumor cell lines, inhibit tyrosine kinase activity and stimulate tyrosine phosphatase activity in colon tumor cell lines. TT-232 TFA inhibits the proliferation of tumor cells, induces apoptosis of tumor cells and shows strong anti-tumor effects. TT-232 TFA can be used in the development of anti-tumor drugs and the study of apoptosis mechanism.
    TT-232 TFA
  • HY-183205
    SSTR5 antagonist 7
    		Antagonist
    SSTR5 antagonist 7 is an orally active SSTR5 antagonist, with an IC50 of 6.2 nM against hSSTR5 and an IC50 of 25 nM against mouse-derived SSTR5. SSTR5 antagonist 7 exerts a sustained hypoglycemic effect. SSTR5 antagonist 7 can be used for the research of diabetes.
    SSTR5 antagonist 7
  • HY-P3953
    Wy 41747
    Wy 41747 is a long-acting Somatostatin analogue. Wy 41747 can be used for the research of diabetes mellitus.
    Wy 41747
  • HY-RS13828
    Sstr3 Rat Pre-designed siRNA Set A
    		Inhibitor

    Sstr3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Sstr3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Sstr3 Rat Pre-designed siRNA Set A
  • HY-P1384
    L803
    		Agonist
    L803 is a selective Somatostatin Receptor Subtype 4 (SST4) agonist. L803 inhibits L-type calcium channel currents (ICa). L803 is promising for research of retinal ganglion cell (RGC) degenerative diseases (e.g., glaucoma).
    L803
Cat. No. Product Name / Synonyms Application Reactivity
Somatostatin Receptor Isoform Comparison

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.